MacroH2A2 knockdown vs control RNA-seq in primary glioblastoma cells

ABSTRACT: Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE149324 | GEO | 2023/02/15

REPOSITORIES: GEO