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Glioblastoma cells treated with MI3 or DMSO

ABSTRACT: Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE149334 | GEO | 2023/02/15

REPOSITORIES: GEO

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MacroH2A2 modulates the self-renewal of glioblastoma cells

Project description:Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2.

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| EGAS00001003493 | EGA

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