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LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues [placenta]

ABSTRACT: We detected de novo endogenous LINE-1 insertions in extraembryonic tissues (chorion frondosum)

ORGANISM(S): Homo sapiens

PROVIDER: GSE149473 | GEO | 2023/03/31

REPOSITORIES: GEO

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LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues [twins]

Project description:We did not detected de novo endogenous LINE-1 insertions in human twins

2023-03-31 | GSE149476 | GEO

LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues [trios]

Project description:We did not detected de novo endogenous LINE-1 insertions in human offsprings

2023-03-31 | GSE149475 | GEO

LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues [somatic tissues]

Project description:We did not detected de novo endogenous LINE-1 insertions in human somatic tissues

2023-03-31 | GSE149474 | GEO

LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-31 | GSE149477 | GEO

LINE-1 retrotransposition impacts the genome of human pre-implantation embryos and extraembryonic tissues [hEMB]

Project description:Using single-cell genomics, we demonstrated that endogenous LINE-1s are mobilized in human pre-implantation embryos

2023-03-31 | GSE149472 | GEO

Taxonomy of placenta cells

Project description:The placenta is considered one of the candidate cell sources in cellular therapeutics because of a large number of cells and heterogenous cell population with myogenic potentials. We first analyzed myogenic potential of cells obtained from six parts of the placenta, i.e., umbilical cord, amniotic epithelium, amniotic mesoderm, chorionic plate, villous chorion (chorion frondosum), , and decidua basalis. Implantation of placenta-derived cells into dystrophic muscles of immunodeficient mdx mice restored sarcolemmal expression of human dystrophin. Co-existence of human and murine nuclei in one myotube and presence of human dystrophin in murine myotube suggests that human dystrophin expression is due to cell fusion between host murine myocytes and implanted human cells. In vitro analysis revealed that cells derived from amniotic mesoderm, chorionic plate, ,and villous chorion efficiently transdifferentiate into myotubes. These cells fused to C2C12 murine myoblasts by in vitro co-culturing, and murine myoblasts start to express human dystrophin after fusion. These results demonstrate that placenta-derived cells, especially extraembryonic mesodermal cells, have a myogenic potential and regenerative capacity of skeletal muscle. Determination of cell specification with the gene chip analysis revealed that each placental cell has a distinct expression pattern. Keywords: Determination of cell specification

2008-05-20 | GSE11510 | GEO

Ectopic histone modification in extra-embryonic tissues influence implantation and placenta development of IVF embryos [RNA-Seq 3]

Project description:To further investigate the relationship between abnormal accumulation of H3K4me3 modification and abnormal embryo development. We injected Kdm5b siRNA, which is an H3K4me3 eraser, at the zygote (PN3-PN4) stage of NM embryos and then examined the transcriptome of extraembryonic ectoderm at E7.5.

2022-05-26 | GSE197914 | GEO

Transcription profiling of mouse placenta cells

2008-06-20 | E-GEOD-11510 | biostudies-arrayexpress

Ectopic histone modification in extra-embryonic tissues influence implantation and placenta development of IVF embryos [ChIP-Seq 2]

2022-05-26 | GSE197920 | GEO

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution

Project description:Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four colorectal cancers arising from colonic polyps, seven pancreatic carcinomas, as well as seven gastric cancers. Surprisingly, we found somatic L1 insertions not only in all cancer types and metastases, but also in colonic adenomas, well-known cancer precursors. Some insertions were also present in low quantities in normal GI tissues, occasionally caught in the act of being clonally fixed in the adjacent tumors. Insertions in adenomas and cancers numbered in the hundreds and many were present in multiple tumor sections implying clonal distribution. Our results demonstrate that extensive somatic insertional mutagenesis occurs very early during the development of GI tumors, probably before dysplastic growth. We assessed the impact of somatic L1 insertions on the expression of the corresponding protein-coding genes by comparing protein abundance in the polyp with the highest number of somatic L1 insertions with that of its paired normal colon using mass spectrometry analysis. Of the 10 validated somatic insertions that were in protein coding regions in the polyp, two proteins – KIAA1217 and WARS2 – were downregulated in the adenoma >90% and >70%, respectively.

2015-08-11 | PXD001626 | Pride

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