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Single cell mapping of breast tumor stroma reveals dynamically evolving compositions of cancer-associated fibroblasts along tumor progression (scRNA-seq dataset)

ABSTRACT: Tumors are complex ecosystems, in which malignant and non-malignant cells engage in continuous interactions. Cancer associated fibroblasts (CAFs) are the most abundant non-malignant cells in the majority of carcinomas. The wide range of activities that CAFs perform suggests a dynamic and heterogeneous composition, yet tumor infiltrating CAF subpopulations remain poorly characterized. Here we used single-cell RNA sequencing, index sorting and bulk RNA sequencing to map CAFs at various stages of tumor progression and metastasis.

ORGANISM(S): Mus musculus

PROVIDER: GSE149635 | GEO | 2020/06/29

REPOSITORIES: GEO

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Single cell mapping of breast tumor stroma reveals dynamically evolving compositions of cancer-associated fibroblasts along tumor progression (bulk RNA-seq dataset)

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