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Reversible and irreversible PAH in a rat model for MCT+Shunt-induced PAH and hemodynamic unloading.

ABSTRACT: PAH was induced by 60mg/kg MCT and an aorto-caval shunt. At different timepoints of PAH progression (day 14, 21 and 28 after MCT-injection), the left lung with PAH was hemodynamically unloading by unilateral orthotopic transplatation into a syngeneic, healthy recipient. All day 14 and 7/10 day 21 transplanted lungs showed reversal of PAH after LTx. All day 28 and 3/10 day 21 transplanted lungs showed PAH progression after LTx. Lung tissue of Reversible and Irreversible PAH and normal controls, acquired at LTx, was compared using RNA-seq.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE149899 | GEO | 2020/07/01

REPOSITORIES: GEO

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