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Genomic comparisons of Salmonella enterica serovar Paratyphi A isolates

ABSTRACT: Comparative genomic analysis of a temporally and locally diverse set of S. enterica ssp I sv Paratyphi A isolates Keywords: ordered

ORGANISM(S): Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella enterica

PROVIDER: GSE1500 | GEO | 2004/07/21

SECONDARY ACCESSION(S): PRJNA90825

REPOSITORIES: GEO

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Genomic comparisons of Salmonella enterica serovar Paratyphi A isolates

Project description:Comparative genomic analysis of a temporally and locally diverse set of S. enterica ssp I sv Paratyphi A isolates Keywords: ordered

2004-07-21 | E-GEOD-1500 | biostudies-arrayexpress

Genomic comparisons of Salmonella enterica serovar Enteritidis isolates

Project description:Comparative genomic hybridization of a temporally and locally diverse set of S. enterica ssp I serovar Enteritidis isolates, and some closely related serovar Dublin and Gallinarum strains, to the sequenced Enteritidis PT4 Keywords: other

2005-08-06 | GSE2242 | GEO

Genomic comparisons of Salmonella enterica serovar Enteritidis isolates

2005-08-06 | E-GEOD-2242 | biostudies-arrayexpress

High-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh

Project description:In this work, we applied an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), and cDNA hybridization-microarray technology to identify S. Paratyphi A transcripts expressed by bacteria in the blood of three patients in Bangladesh. In total, we detected 1798 S. Paratyphi A mRNAs expressed in the blood of infected humans (43.9% of the ORFeome). Of these, we identified 868 in at least two patients, and 315 in all three patients. S. Paratyphi A transcripts identified in at least two patients encode proteins involved in energy metabolism, nutrient and iron acquisition, vitamin biosynthesis, stress responses, oxidative stress resistance, and pathogenesis. A number of detected transcripts are expressed from PhoP and SlyA-regulated genes associated with intra-macrophage survival, genes contained within Salmonella Pathogenicity Islands (SPIs) 1-4, 6, 10, 13, and 16, as well as RpoS-regulated genes. The largest category of identified transcripts are those encoding proteins with unknown function. When comparing level of bacterial mRNA detection using in vivo samples collected from infected patients to samples from in vitro grown organisms, we found significant differences for 347, 391, and 456 S. Paratyphi A transcripts in each of three individual patients (approximately 9.7% of the ORFeome). Of these, expression of 194 transcripts (4.7% of ORFs) was concordant in two or more patients, and 41 in all patients. Genes encoding these transcripts are contained within SPI-1, 3, 6 and 10, are PhoP-regulated genes, are involved in energy metabolism, nutrient acquisition, drug resistance, or are uncharacterized genes. Using quantitative RT-PCR, we confirmed increased gene expression in vivo for a subset of genes identified in our analyses. We compared transcriptional profiles of S. Paratyphi A from the blood of infected humans to S. Paratyphi A grown in vitro. Replicates and dye-swaps were performed.

2010-09-06 | E-GEOD-22958 | biostudies-arrayexpress

SARB48_hydrogen_peroxide_2mM_DNA

Project description:Gene content of Salmonella enterica sv Paratyphi C SARB48 5h after treatment with 2mM hydrogen peroxide Keywords: parallel sample

2004-05-10 | GSE825 | GEO

SARB48_hydrogen_peroxide_2mM_DNA

Project description:Gene content of Salmonella enterica sv Paratyphi C SARB48 5h after treatment with 2mM hydrogen peroxide

2010-06-09 | E-GEOD-825 | biostudies-arrayexpress

High-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh

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Gene expression response of Salmonella enterica serovar Enteritidis phage type 8 to subinhibitory concentrations of trans-cinnamaldehyde and eugenol

Project description:Transcriptional profiles of mid-exponentially growing Salmonella enterica sv Enteritidis PT8 cultures in response to exposure to trans-cinnamaldehyde (0.01%; 0.75mM) or eugenol (0.04%; 2.46mM)

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Salmonella enterica subsp. enterica serovar Paratyphi A

Project description:Salmonella enterica subsp. enterica serovar Paratyphi A Raw sequence reads

| PRJNA775815 | ENA

Comparative analysis of Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes

Project description:Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal Salmonella serovars (Typhimurium and Enteritidis) have a broad host range and predominantly cause gastroenteritis. In this study, we compared the core proteomes of Salmonella Typhi, Paratyphi A, Typhimurium and Enteritidis using contemporary proteomics. Five isolates, covering different geographical origins, and one reference strain per serovar were grown in vitro to the exponential phase. Protein levels of orthologous proteins between serovars were compared and subjected to gene ontology term enrichment and inferred regulatory interactions. Differential expression of the core proteomes of the typhoidal serovars appears mainly related to cell surface components and, for the non-typhoidal serovars, to pathogenicity. Our findings may guide future development of novel diagnostics and vaccines, and understanding of disease progression.

2019-05-13 | PXD011154 | Pride

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