The transcriptional profile of neutrophils in different organs during pancreatic cancer

ABSTRACT: It was previously demonstrated that myeloid cells assume a distinct transcriptional profile when infiltrating the brain during chronic inflammation. We demonstrated that neutrophils infiltrate the brain during pancreatic cancer. To determine if the transcriptional profile of brain-infiltrating neutrophils is distinct from those infiltrating other organs, we compared the gene signatures of brain-infiltrating neutrophils, circulating neutrophils, liver-infiltrating neutrophils, and tumor-infiltrating neutrophils to that of circulating neutrophils from healthy mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE150061 | GEO | 2020/05/08

REPOSITORIES: GEO