Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

ABSTRACT: Translation of NRF1/NRF2 -mediated liver tissue biomarkers to an in vitro assay using an advanced micropatterned co-culture system (HEPATOPAC®) with primary hepatocytes from male Wistar-Hannover rats or humans

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE150069 | GEO | 2020/06/22

REPOSITORIES: GEO