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Gene expression profiles of primary LN3 T-ALL cells and wild-type T-lineage cells from the thymus and spleen

ABSTRACT: T cell acute lymphoblastic leukemia (T-ALL) develops spontaneously in the thymus of LN3 mice and infiltrates secondary organs, including spleen. We found leukemia-associated myeloid cells from the spleens of overtly sick LN3 mice significantly support survival of splenic T-ALL cells, but not tumor-free splenic CD8+ T cells, in vitro. To determine gene signatures induced in T-ALL cells by tumor-supportive myeloid cells, but not induced in wild-type T cells, we transcriptionally profiled primary LN3 T-ALL cells from leukemic mice and T-lineage cells from tumor-free mice, isolated from thymuses and spleens, via RNA-sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE150096 | GEO | 2020/07/22

REPOSITORIES: GEO

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