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HDAC4 controls senescence and aging by safeguarding the epigenetic identity and ensuring the genomic integrity

ABSTRACT: Purpose: Define HDAC4 signature Outcome: HDAC4 is required for the repression of a senescence signature. HDAC4 KO promotes the expression of inflammatory genes, the derepression of ERVs and the accumulation of DNA damage. All together these signalling pathways lead to permanent cell-cycle arrest in low grade tumor cells and pre-transformation models, while they weaken the replicative potential of primary normal cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE150427 | GEO | 2021/04/06

REPOSITORIES: GEO

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HDAC4 controls senescence and aging by safeguarding the epigenetic identity and ensuring the genomic integrity

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