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Effects of 4-nitrophenol on testicular somatic cells [TM4]

ABSTRACT: These data suggested that TM3 and TM4 cells showed different responses to PNP, which might mediate different toxic mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE150448 | GEO | 2023/05/06

REPOSITORIES: GEO

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Effects of 4-nitrophenol on testicular somatic cells [TM3]

Project description:These data suggested that TM3 and TM4 cells showed different responses to PNP, which might mediate different toxic mechanisms.

2023-05-06 | GSE150447 | GEO

RNA-seq of C18-4 and TM4 cells samples from different M5 receptor modification groups

Project description:The goat of this project is to explore M5 receptor regulation spermatogenesis. We tried to search the mechanism of M5 receptor regulation spermatogenesis. RNA-seq of C18-4 and TM4 cells samples from different groups: C3NC, M5 knockdown in C18-4, TM3NC, M5 knockdown in TM4 cells. The cell were transfected with virus with inhibition of M5 expression ( M5 gene knockdown).

2021-06-16 | GSE142618 | GEO

Genome-wide analysis of gene expression in TM4 Sertoli cells following siRNA-mediated Gata4 inhibition

Project description:The effects of Gata4 inhibition on global gene expression in TM4 Sertoli cells was analyzed. Using microarray analysis we identified a set of genes that are downregulated or upregulated following siRNA-mediated silencing of Gata4 in the murine Sertoli cell line TM4. Among the downregulated genes were regulators of blood-testtis barrier function and lactate metabolism. TM4 cells were transfected with non-targeting (NT) siRNA and Gata4 siRNA respectively. 72h post transfection cells were lysed and RNA was extracted.

2016-03-17 | GSE74471 | GEO

Effects of 4-nitrophenol on testicular somatic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-06 | GSE150449 | GEO

Talaromyces marneffei strain:TM4

Project description:Talaromyces marneffei strain:TM4 Genome sequencing and assembly

| PRJNA322422 | ENA

Genome-wide analysis of gene expression in TM4 Sertoli cells following siRNA-mediated Gata4 inhibition

Project description:The effects of Gata4 inhibition on global gene expression in TM4 Sertoli cells was analyzed. Using microarray analysis we identified a set of genes that are downregulated or upregulated following siRNA-mediated silencing of Gata4 in the murine Leydig tumor cell line mLTC-1. Among the downregulated genes were enzymes of the androgen biosynthetic pathway. TM4 cells were transfected with non-targeting (NT) siRNA and Gata4 siRNA respectively. 72h post transfection cells were lysed and RNA was extracted. n=3 of each sample group; control samples are samples 3-6 (TM4 cells treated with non-targeting siRNA)

2016-03-17 | E-GEOD-74471 | biostudies-arrayexpress

Assessment of zearalenone-induced cell survival and global gene regulation in mouse TM4 Sertoli cells

Project description:Zearalenone (ZEA) is a non-steroidal xenoestrogen mycotoxin produced by many Fusarium fungal species, which are common contaminants of cereal crops destined for worldwide human and animal consumption. ZEA has been linked to various male reproduction problems including decreased fertility potential. In this study, the direct impact of ZEA on the immature Sertoli TM4 cell line was evaluated. Results showed that high concentration of ZEA increase reactive oxygen species via the activation of MAPK signaling. Transcriptome analysis was performed on TM4 cell line treated with ZEA and genes involved in sex differentiation (Fgfr2, Igf1, Notch1, Sox9) and extracellular matrix (ECM) formation (Ctgf, Fam20a, Fbn1, Mmp9, Postn, Sparcl1, Spp1) were identified at the center of the functional protein association network suggesting that ZEA could be detrimental to the early steps of Sertoli cell differentiation.

2022-03-07 | GSE185111 | GEO

Toxicogenomic Screen of Replacements for bis(2-ethylhexyl) phthalate (DEHP) Using the Immortalized TM4 Sertoli Cell Line

Project description:Phthalate plasticizers are being phased out of consumer products because of their endocrine disrupting properties. This has resulted in a need to find safe alternatives that can plasticize polyvinyl chloride (PVC) while being inexpensive and biodegradable. We aim to study the toxicogenomic profile of mono-(2-ethylhexyl) phthalate (MEHP, the active metabolite of bis(2-ethylhexyl) phthalate, DEHP), the commercial plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), and three plasticizers in development (1,4 butanediol dibenzoate (BDB), dioctyl succinate (DOS), and dioctyl maleate (DOM)) using the immortalized TM4 Sertoli cell line.

2015-08-06 | GSE66812 | GEO

RNA-seq of C18-4 and TM4 cells samples from different M5 receptor modification groups

Project description:RNA-seq of C18-4 and TM4 cells samples from different M5 receptor modification groups

| PRJNA597760 | ENA

Nitrophenol (o-nitrophenol) treatment with 3 mM for 2 h

Project description:The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be carefully controlled and monitored in order to minimize potential damage. DNA microarray technology has become an important new technique in toxicology. We are using the yeast Saccharomyces cerevisiae as a model organism for toxicological study because it is a simple, fast-growing eukaryote that has been thoroughly characterized. In order to evaluate toxicity by newly synthesized or mixture chemicals, toxicity-induced gene expression alteration profiles by known chemicals should be collected. In our study, cells need to be exposed with same experimental cellular condition, semi lethal (IC50), respectively. In the case of o-nitrophenol (CAS; 88-75-5), the exposure dose was decided as 3 mM by growth curve with continuously diluted exposure. o-Nitrophenol is one of the nitrogen compounds, and 2-nitrophenol is reported to be less toxic than 4-. This substrate is suspected to be cardiovascular or blood toxicant, neurotoxicant. Keywords: stress response

2007-11-01 | GSE9227 | GEO

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