Genome-wide DNA methylation analysis in cfDNA from pancreatic cancer patients

ABSTRACT: Heterogeneity in DNA methylation status may exist between primary tumors and cfDNA. We compared the genome-wide DNA methylation status between FNA sample of pancreatic tumor and cfDNA samples from the same patients. MBD-sequencing (seq) was performed in paired samples of FNA and cfDNA from two patients. The majority of DNA methylation peaks overlapped in FNA and cfDNA samples (82.6% and 82.9% in patients #1 and #73, respectively). DNA methylation levels of each gene in FNA and cfDNA samples were highly correlated with each other (r=0.98 and 0.97 in samples 1 and 73, respectively)

ORGANISM(S): Homo sapiens

PROVIDER: GSE150468 | GEO | 2020/05/21

REPOSITORIES: GEO