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Transcriptome-wide regulation of host m6A mRNA methylation by malaria parasite infection

ABSTRACT: N6-Methyladenosine (m6A) modification has been found to play important roles in diverse pathogen infections and host responses, here we report host m6A mRNA transcriptome profiles regulated by the infections of two strains of malaria parasite Plasmodium yoelii (N67 and N67C). We showed that malaria infection can regulate host m6A mRNA modification and reprogram host m6A mRNA methylome by mediating corresponding m6A catalytic enzyme levels. Our data suggested m6A modification as a significant transcriptome-wide mark during host-malaria interactions.

ORGANISM(S): Mus musculus

PROVIDER: GSE150546 | GEO | 2021/05/24

REPOSITORIES: GEO

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Transcriptome Survey of Malaria Parasite Liver Stages

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