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Monocyte-derived macrophages (MDMs) treated with siRNA non-targeting control and pooled GAPLINC siRNAs

ABSTRACT: Examination of differentially expressed genes in GAPLINC-knockdown MDMs

ORGANISM(S): Homo sapiens

PROVIDER: GSE150572 | GEO | 2021/02/01

REPOSITORIES: GEO

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Monocyte-derived macrophages (MDMs) treated with siRNA non-targeting control and pooled GAPLINC siRNAs

Project description:Monocyte-derived macrophages (MDMs) treated with siRNA non-targeting control and pooled GAPLINC siRNAs

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The mRNA and lncRNA profiles of the monocytes-derived macrophages (MDMs) and tumor associated macrophages (TAMs)

Project description:We compared the lncRNA expression profile of MDMs and TAMs. TAMs were polarized by treating human monocytes-derived macrophages (MDMs) with the conditioned media of MDA-MB-231 cells.

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Interferon-beta-inducible genes in human monocyte-derived macrophages (MDMs)

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The mRNA and lncRNA profiles of the extracellular vesicle from monocytes-derived macrophages (MDMs) and tumor associated macrophages (TAMs)

Project description:We compared the lncRNA expression profile of extracellular vesicle from MDMs and TAMs. TAMs were polarized by treating human monocytes-derived macrophages (MDMs) with the conditioned media of MDA-MB-231 cells.

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Transcriptome profile of the host antiviral response to Chikungunya virus infection in human monocyte-derived macrophages (MDMs)

Project description:Chikungunya virus (CHIKV) infection is characterized by alterations in gene expression profile on host cells that consequently lead to an immune response. Here, we used RNA sequencing to analyze the mRNA expression profile in human monocyte-derived macrophages (MDMs) infected with a Colombian clinical isolate of CHIKV at 6 and 24 hpi. analyze the mRNA expression profile in the human monocyte-derived macrophages infected at 6 and 24 hrs with a Colombian clinical isolate of Chikungunya virus.

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cART Treated monocyte derived macrophages

Project description:primary human monocyte derived macrophages (MDMs) treated with antiretrovirals, specifically Atripla (A) or Triumeq (T)

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Mycobacterium tuberculosis induced interferon pathways distinguish responses of Human Alveolar Macrophages from Monocyte-Derived Macrophages

Project description:Alveolar macrophages (AMs) and recruited monocyte-derived macrophages (MDMs) mediate early lung immune responses to Mycobacterium tuberculosis (Mtb). Using paired human AMs and MDMs from 6 healthy volunteers, we investigated transcriptional profiles in responses to Mtb. We found 681 genes that were Mtb-dependent in AMs compared to MDMs, 107 that were induced in both cell types but in different directions, and 4538 that were Mtb-dependent in MDMs but not AMs (FDR < 0.05). We found that IFNA Response and IFNG Response were the top two gene sets selectively induced in Mtb-infected AM. Thus, a second experiment utilized MDMs treated with IFNA1, IFNA8, IFNE, or IFNL1 found that IFNA8 modulated Mtb-induced pro-inflammatory cytokines and, compared to other interferons,stimulated unique transcriptional profiles.

2024-03-20 | GSE236156 | GEO

Affymetrix microarray of human monocyte derived macrophages following challenge with Streptococcus pneumoniae with or without pneumolysin

Project description:Transcriptional profiling of primary monocyte derived macrophages (MDMs) comparing control untreated MDMs with MDMs exposed with Serotype 2 Streptococcus pneumoniae (D39) strain (MOI 10) for 3 hours) Three-condition experiment, control MDMs vs. D39 infected MDMs vs Stop infected MDMs. Biological replicates: 3 control replicates, 3 infected D39 replicates and 3 infected penumolysin deficient (STOP) MOI 10.

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miRNA profiles in unstimulated and TLR stimulated MDMs

Project description:Macrophages play a crucial role in HIV-1 pathogenesis. Toll-like receptors (TLRs) are fundamental for innate and adaptive immune responses, but their role in HIV-1 infection is still incompletely understood. The TLR3 and TLR4 ligands poly(I:C) and LPS are known to modulate HIV-1 infection of and replication in monocyte-derived macrophages (MDMs), but the mechanism is incompletely understood. We found that MDMs stimulation with poly(I:C) or LPS abrogated infection by CCR5-using, macrophage-tropic HIV-1, or by VSV-G-pseudotyped HIV-1 virions, while TLR7 and TLR9 agonists Imiquimod and CpG only reduced infection to varying extent. Suppression of infection, or lack thereof, did not correlate with differential effects on CD4 or CCR5 expression, type I interferon induction, or production of pro-inflammatory cytokines. Furthermore, integrated pro-viruses were readily detected in unstimulated, TLR7- and TLR9-stimulated cells, but not in TLR3- or TLR4-stimulated MDMs, suggesting the alteration of post-entry, pre-integration event(s). MicroRNA (miRNA) microarray and real time PCR demonstrated increased miR-155 levels in MDMs upon TLR3/4, but not TLR7, stimulation, and a miR-155 inhibitor partially restored infectivity in poly(I:C)-stimulated MDMs. Finally, miR-155 over-expression in MDMs and cell lines remarkably diminished HIV-1 infection, inducing an accumulation of late reverse transcription products, concurrently with a decrease in mRNA levels of several HIV-1 dependency factors involved in nuclear import of pre-integration complexes. Our results suggest that miR-155 may target mRNA(s) for host cell protein(s) that either participate in or facilitate post-entry, pre-integration events, resulting in severely diminished HIV-1 infection. miRNA profiles were investigated in total RNA isolated from unstimulated and TLR3-, TLR4- and TLR7-stimulated human MDMs from a single normal donor

2011-12-14 | E-GEOD-34428 | biostudies-arrayexpress

miRNA profiles in unstimulated and TLR stimulated MDMs

2011-12-14 | GSE34428 | GEO

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