Transcriptomics

Dataset Information

42

Expression profiling of laser-microdissected tissue from APPPS1 plaque-depositing mouse model of Alzheimer's disease


ABSTRACT: Amyloid-ß (Aß) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for Aß-mediated neuropathology, we performed a gene expression analysis on frontal neocortical brain tissue of APPPS1 mice compared to their littermate controls. Overall design: 4 samples; 2 biological replicates of each condition = 2 transgenic versus 2 non-transgenic mice; no amplification of total RNA; Cy3/Cy5 dye-swap design

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

ORGANISM(S): Mus musculus  

SUBMITTER: Wouter Van Delm  

PROVIDER: GSE15058 | GEO |

SECONDARY ACCESSION(S): PRJNA123155

REPOSITORIES: GEO

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