Heat shock stimulates genomic instability and phenotypic variations in yeast

ABSTRACT: Yeast Saccharomyces cerevisiae has been widely used as a model system for studying genomic instability. In this study, heat-shock-induced genomic alterations were explored in the heterozygous diploid yeast strain JSC25-1. In combination of the whole-genome microarray, the patterns of chromosomal instability induced by heat shock could also be explored at a whole genome level. Using this system, we found heat-shock treatment resulted in hundreds-fold higher rate of genomic alterations, including aneuploidy and loss of heterozygosity (LOH).

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE150711 | GEO | 2020/05/18

REPOSITORIES: GEO