Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy

ABSTRACT: We developed a novel, rapidly-progressing, severe murine model of C3G by replacing the mouse C3 gene with the human C3 homologue using Velocigene® technology. We conducted functional, histological, molecular and pharmacologic assays to characterize the presentation of renal disease and useful pharmacologic interventions in the humanized C3 (C3hu/hu) mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE150838 | GEO | 2020/05/20

REPOSITORIES: GEO