Transcriptomics,Genomics

Dataset Information

28

Time-course of gene expression in BMDCs stimulated with gamma-PGA nanoparticles


ABSTRACT: The gene expression levels in murine bone marrow-derived dendritic cells treated with γ-PGA NPs were examined by oligonucleitide microarray at 6, 12 and 24 hours. The gene expression of proinflammatory chemokines, cytokines, and costimulatory molecules was upregulated considerably in DCs treated with γ-PGA NPs at 6 hours. Overall design: The gene expression in murine bone marrow-derived dendritic cell was measured at 6, 12 and 24 hours after exposure to γ-PGA NPs (300 µg/ml). Three independent experiments were performed.

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

SUBMITTER: Takayuki Hamasaki  

PROVIDER: GSE15089 | GEO | 2009-03-05

SECONDARY ACCESSION(S): PRJNA114791

REPOSITORIES: GEO

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Publications

Modulation of gene expression related to Toll-like receptor signaling in dendritic cells by poly(gamma-glutamic acid) nanoparticles.

Hamasaki Takayuki T   Uto Tomofumi T   Akagi Takami T   Akashi Mitsuru M   Baba Masanori M  

Clinical and vaccine immunology : CVI 20100310 5


Poly(gamma-glutamic acid) (gamma-PGA) nanoparticles (NPs) have previously been reported as an efficient antigen delivery system with adjuvant activity. In this study, the gene expression in murine bone marrow-derived dendritic cells (DCs) treated with gamma-PGA NPs was examined by oligonucleotide microarray analysis and compared with that in cells treated with other adjuvants. The gene expression of proinflammatory chemokines, cytokines, and costimulatory molecules was upregulated considerably i  ...[more]

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