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Next Generation Sequencing of whole SAS and FaDu spheroids transcriptomes treated with Hyperthermia (HT) and Radiation therapy (RT)

ABSTRACT: By employing a global gene expression profiling, we performed the differential gene expression analysis and the analysis of the molecular pathways which are deregulated in Hyperthermia (HT) and Radiation therapy (RT) treated SAS and FaDu spheroids from the head-and-neck cancer cell lines. The RNA-Seq analysis was done on FaDu and SAS spheroids treated with clinically relevant HT dose of 42.5°C for 60 minutes alone or in combination of single dose irradiation of 7 and 10 Gy for FaDu and SAS, respectively. The main pathways and networks modulated by the treatments (0.5 h after treatment) were identiﬁed using Gene Ontology (GO) enrichment analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE150922 | GEO | 2021/07/01

REPOSITORIES: GEO

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