Mammary tumors in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5

ABSTRACT: Stat5 is a latent transcription factor that regulates essential growth and survival functions in normal cells. Constitutive activity of Stat5 and the involvement of its C-terminally truncated variant have been implicated in blood cell malignancies and mammary or breast cancer. To distinguish the individual contributions of the Stat5 variants to mammary tumorigenesis, global gene-expression profiling was performed on transgenic STAT5-induced tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE15119 | GEO | 2009/03/06

SECONDARY ACCESSION(S): PRJNA114871

REPOSITORIES: GEO