RNA Sequencing on hippocampal tissue after ASO treatment overtime in MECP2 duplication mice

ABSTRACT: To understand the response of MECP2-regulated genes to the ASO treatment, we performed RNA-sequencing at multiple timepoints on hippocampal tissue following ASO treatment. It shows that the abnormal transcriptomic profile of hDup mice is significantly rescued 2 weeks after the treatment. Long-term partial rescue of the gene expression was observed at 5 weeks and until 16 weeks after the treatment as the transcriptomic profile does not cluster with the control-ASO treated mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE151222 | GEO | 2022/05/26

REPOSITORIES: GEO