Landscape of genome-wide DNA methylation profile of colorectal cancer metastasis

ABSTRACT: Genome-wide DNA methylation of colorectal cancer patients with lymph node metastases showed global loss of DNA methylation in CG-poor, non-CpG island (CGI) regions. Overall CGI methylation was increased in tumour samples. Differential methylation analysis of CGIs identified 60 putative biomarkers, with >20% increase in DNA methylation in both primary tumour and metastasis samples compared to normal adjacent tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151318 | GEO | 2020/11/02

REPOSITORIES: GEO