Genomics

Dataset Information

0

Riboflavin depletion impairs cell proliferation in intestinal cells: Identification of mechanisms and consequences


ABSTRACT: Microarray analysis has been applied to the cell proliferation in a human colonic cel line, Caco-2. We have shown previously that a moderate riboflavin depletion around weaning has a profound impact on the structure and function of the small intestine of the rat, which is not reversible following riboflavin repletion. In this study we have modelled riboflavin deficiency in a human cell line, shown irreversible loss of cell viability associated with impaired mitosis and identified candidate effectors of riboflavin depletion in the cell. The aim of the present study is to develop a cell culture model of riboflavin depletion and analyse its behaviour using a using a combination of cell biology approaches including microarray analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15132 | GEO | 2009/03/06

SECONDARY ACCESSION(S): PRJNA114951

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-15132 | biostudies-arrayexpress
2017-05-16 | GSE98927 | GEO
2018-02-21 | GSE107538 | GEO
2018-02-28 | GSE111207 | GEO
2010-01-01 | GSE18417 | GEO
| E-GEOD-18417 | biostudies-arrayexpress
2017-11-05 | GSE96702 | GEO
2009-09-20 | GSE12873 | GEO
| E-GEOD-12873 | biostudies-arrayexpress
| PRJNA102855 | ENA