EGR1 regulates metastatic potential of v-src transformed chicken sarcoma cell lines

ABSTRACT: A model of tumor metastasis based on v-src transformed immortalized cell lines was developed. The model consists of highly metastatic PR9692 cell line and a derived clone PR9692-E9 which has lost the metastatic abilities. Introduction of exogenous EGR1 gene into the non-metastasizing PR9692-E9 cells completely restores the metastatic potential. Revealed changes in gene expression provide insight into the molecular mechanisms contolling metastatic behavior of sarcoma cells.

ORGANISM(S): Gallus gallus

PROVIDER: GSE15141 | GEO | 2010/03/05

SECONDARY ACCESSION(S): PRJNA114903

REPOSITORIES: GEO