Transcriptomics

Dataset Information

0

β cell specific Crif1 haploinsufficiency effect.


ABSTRACT: CRIF1 is a mitochondrial protein essential for the synthesis and formation of the OxPhos complex in the inner mitochondrial membrane. Beta cell specific Crif1 haploinsufficiency resulted in defect of first phase insulin secretion, and caused islet cell composition change as well as proliferation of beta cell for a compensation to maintain metabolic homeostasis. These results suggest that mitochondrial OxPhos function of beta cell has roles for beta cell compensation as well as insulin secretion.

ORGANISM(S): Mus musculus

PROVIDER: GSE151708 | GEO | 2022/07/21

REPOSITORIES: GEO

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