Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility

ABSTRACT: Loss of the nuclear-encoded brain-specific arginine UCU tRNA, n-Tr20, gene increases seizure threshold in mice, and alters inhibitory neurotransmission in the hippocampus. We investigated the molecular impact of loss of n-Tr20 expression on the trancriptome and translatome in the forebrain and hippocampus of multiple n-Tr20 mutant and control strains. Loss of n-Tr20 altered translation initiation by activating the integrated stress response and suppressing mTOR signaling, the latter of which contributes to the enhanced GABAergic transmission. 

ORGANISM(S): Mus musculus

PROVIDER: GSE151742 | GEO | 2020/06/04

REPOSITORIES: GEO