Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

ABSTRACT: UHRF1 is a key regulator of DNA methylation maintenance. In this study, we investigated whether acetylation of UHRF1 affects its hemimethylated DNA binding affinity and alters genome-wide DNA methylation pattern. We observed that acetylation of UHRF1 is regulated by HDAC1 and PCAF. We investigated DNA methylation profile of HDAC1 depleted HCT116 cell with control cell.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151861 | GEO | 2020/06/06

REPOSITORIES: GEO