Epigenome analyses of HCT116 cells stably expressing UHRF1 mutant [Illumina EPIC]

ABSTRACT: UHRF1 is a key regulator of DNA methylation maintenance. In this study, we investigated whether acetylation of UHRF1 affects its hemimethylated DNA binding affinity and alters genome-wide DNA methylation pattern. We show that cells with mutation in K490 of UHRF1 have distinct methylation profile versus wildtype UHRF1 expressing cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151862 | GEO | 2020/06/06

REPOSITORIES: GEO