C9orf72 in myeloid cells suppresses STING-induced inflammation

ABSTRACT: In this study we report that loss of C9orf72 expression in myeloid cells drives STING/type I interferon mediated autoimmunity and enhanced tumor immunity in mice. Additionally, we show that the immunophenotypic signature identified in C9orf72-/- mice is present in blood derived macrophages, whole blood and autopsy brain tissue from C9orf72 repeat expansion ALS/FTD patients.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE151936 | GEO | 2020/09/03

REPOSITORIES: GEO