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Sustained activation of AMPK enhances differentiation of human iPSC-derived cardiomyocytes via sirtuin activation

ABSTRACT: Lee and colleagues demonstrate that sustained activation of AMPK enhances differentiation of iPSC-derived cardiomyocytes. Sustained AMPK activation decreased histone acetylation at known target sites for nuclear-localized sirtuins, suggesting that AMPK activation enhances sirtuin activity. AMPK-induced sirtuin-mediated deacetylation of histone proteins may regulate chromatin accessibility and enhance cardiomyocyte differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE152265 | GEO | 2020/06/12

REPOSITORIES: GEO

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