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RNA-Seq and H3K27ac ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE152526 | GEO | 2023/06/14

REPOSITORIES: GEO

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Histone H3K27ac modification profiling by ChIP-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

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Genome-wide transcriptome in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure [RNA-seq]

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DNA methylation profiling by MBD-Seq in the mouse seminal vesicles (SVs) and uterus (U) following neonatal DES exposure

2018-03-27 | GSE102449 | GEO

Gene expression profiling in the seminal vesicles (SVs) from neonatal DES-treated mice [array]

Project description:DES is a synthetic estrogen that is associated with adverse effects on reproductive organs. Our group has employed estrogen receptor (ER) α knockout (αERKO) mice to gain insight into the contribution of ER-dependent pathways in mediating the effects of neonatal DES exposure in female and male reproductive tract tissues. The objective of this study is to compare gene expression profiles between the WT-veh and -DES groups or αERKO-veh and -DES from the adult male mice (week 10) of the SV tissues to identify differential genes.

2018-03-27 | GSE95314 | GEO

Gene expression and DNA methylation profiling in the seminal vesicles (SVs) from neonatal DES-treated mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-03-27 | GSE102450 | GEO

Gene expression and DNA methylation profiling in the seminal vesicles (SVs) from neonatal DES-treated mice

Project description:Gene expression and DNA methylation profiling in the seminal vesicles (SVs) from neonatal DES-treated mice

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Neonatal Genistein Exposure and Glucocorticoid Signaling in the Adult Mouse Uterus.

Project description: Not available

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Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure.

Project description: Not available

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ERα Dependent Alterations in the Epigenetic Landscape of the Mouse Uterus Following Neonatal Estrogen Exposure [ChIP-Seq]

Project description:Abstract. Very little is known regarding how hormonal exposures impact the epigenetic landscape of developing tissues in the context of a whole organism, in contrast to the impact on cultured cells. Here we took a global approach to understanding how neonatal exposure to the xenoestrogen, diethylstilbestrol (DES), alters the uterine epigenome. RNA-seq and ChIP-seq (H3K4me3, H3K27me3, H3K27ac and H3K4me1) were performed on DES-treated and control uteri. The most striking finding was differential association of H3K27ac and H3K4me1 at typical and super-enhancer regions of 79% of altered genes. These peaks overlapped with previously reported estrogen receptor a (ERα) ChIP-seq peaks. Conditional uterine deletion of ERα (Esr1cKO) conferred protection of 88% of altered genes. H3K27ac ChIP-seq on Esr1cKO samples showed that 72% of protected genes had a differential H3K27ac enhancer. These data suggest that DES regulates gene expression in the neonatal mouse uterus by H3K27ac association at ERα binding sites near estrogen-regulated genes.

2018-03-27 | GSE104401 | GEO

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