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A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App[NL-F/NL-F] knock-in mouse model

ABSTRACT: To investigate the effects of diabetic conditions on the development of AD pathology, we fed wild-type and Alzheimer's disease model (App[NL-F/NL-F]) mice with control or high fat diet from 6 months after birth for 12 months, then examined behavior, brain pathology and gene expression profiles. Both groups of mice fed with high fat diet exhibited diabetic conditions, and App[NL-F/NL-F] mice exhibited aggravated cognitive impairment with enhanced Alzheimer's disease pathology.

ORGANISM(S): Mus musculus

PROVIDER: GSE152539 | GEO | 2021/06/30

REPOSITORIES: GEO

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Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice

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