Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide association study of body weights in Hu sheep

ABSTRACT: Body weight (BW) is a critical economic trait for meat production in sheep. The current study aimed to perform a genome-wide association study (GWAS) to detect significant single-nucleotide polymorphisms (SNPs) that are associated with BW in Hu sheep.

ORGANISM(S): Ovis aries

PROVIDER: GSE152717 | GEO | 2020/06/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Ovis aries strain:Hu sheep 1 | breed:Hu sheep

Project description:Hu sheep adipose RNA seq

| PRJNA576088 | ENA

Genome-wide association study of body weights in Hu sheep

Project description:Genome-wide association study of body weights in Hu sheep

| PRJNA640179 | ENA

A single-cell atlas of the single versus multiple parous Hu Sheep ovary

Project description:Follicular development is a highly coordinated process in Hu sheep. Follicle-cyclic recruitment, spatial displacement, follicle atresia, and ovulation are implicated events resulting from the somatic cells' release of molecular signals. Hu sheep is a high-quality sheep breed with high fecundity in China and is ideal for investigating high reproductive traits. In the current study, the sheep with lambing number ≥3 in three consecutive lambing records were assigned to the HLS group, and lambing number = 1 as the LLS group selected from the same farm with three consecutive lambings. Three randomly picked ewes were slaughtered within 12 h of estrus, and unilateral ovarian tissue was collected and analyzed by single-cell RNA sequencing in each group. A total of five types of somatic cells were identified, and corresponding expression profiles were mapped in the ovaries of the Hu sheep. Additionally, the results of the difference in ovary somatic cell expression profiles between HLS and LLS present that the differences between multiples vs. singleton Hu sheep were mainly clustered in the GCs. In addition, 4 granulosa cell subtypes were identified. GeneSwitches results revealed the opening of JPH1 expression and the closure of LOC101112291, which leads to different evolutionary directions of the granular cells. The expression levels of FTH1 and FTL in GCs of Hu sheep in the HLS group were significantly higher, which inhibited necroptosis and ferroptosis of mural-GCs from decreasing follicular atresia. This study constructed the cellular atlas of the ovary and revealed related biological characteristics at the cellular molecular level. It provides a theoretical basis for the mechanisms underlying the differences in ovulation numbers, which contributes to breeding high-fertility sheep and molecular genetics-based selection.

2023-08-15 | GSE233801 | GEO

Genome-wide association studies for sheep growth and meat production traits using Illumina OvineSNP50 BeadChip

Project description:Mear prodution is the most important trait for sheep. In this study, we performed a Genome-wide association study (GWAS) by using Illumina Ovine SNP50 BeadChip in 329 purebred sheep phenotyped for 11 growth and meat production traits (birth weight, weaning weight, 6-month weight, eye muscle area, fat thickness, pre-weaning gain, post-weaning gain, daily weight gain, height at withers , chest girth and shin circumference). A total of 319 sheep and 48,198 SNPs were fitted using TASSEL 3.0 software as random effects in a mixed linear model. 36 chromosome-wise significant SNPs were identified for 7 traits and 10 of them reached genome-wide significance level consistently for post-weaning gain. Gene annotation was implemented based on the latest version3.1 ovine genome sequence (released October 2012), and meanwhile we referenced genomic information of human, bovine, mouse and rat. More than one-third SNPs (14 out of 36) were located within ovine genes , some other were located close to ovine genes (878bp-398165bp apart). 329 sheep DNA were scanned using OvineSNP50 Beadchip and the association is done between the SNP data and 11 different meat prodution traits

2015-05-01 | E-GEOD-46231 | biostudies-arrayexpress

Genome-wide Analysis Reveals Extensive Changes in LncRNAs during Skeletal Muscle Development in Hu sheep

Project description:To explore functional lncRNAs during sheep muscle growth, we systematically investigated lncRNAs using strand-specific Ribo-Zero RNA Sequencing at three key developmental stages of Hu sheep (110-day fetus, 5-day-old lamb and 2-year-old adult)

2017-07-21 | GSE101669 | GEO

Ovis aries breed:Hu sheep

Project description:Ovis aries breed:Hu sheep Raw sequence reads

| PRJNA759095 | ENA

Ovis aries breed:Hu sheep

Project description:Ovis aries breed:Hu sheep Raw sequence reads

| PRJNA854211 | ENA

Hu sheep rumen microbial metatranscriptome

Project description:Hu sheep rumen microbial metatranscriptomics raw sequence reads

| PRJNA517369 | ENA

Ovis aries breed:Hu sheep

Project description:Ovis aries breed:Hu sheep Raw sequence reads