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Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE152748 | GEO | 2020/12/17

REPOSITORIES: GEO

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Fate and functional roles of Prominin 1+ cells in liver injury and cancer.

Project description: Not available

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Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [Quant-seq]

Project description:Purpose: The goal of the experiment is to obtain RNAseq profiles of Prom1+ Ductular Reactive Progenitors (DRPs) from mouse model of severe alcoholic liver injury Method: mRNA-seq analysis was performed in FACS sorted Prom1+CD49f+CD45-, Prom1-CD49f+CD45-, Prom1+CD49f+CD45+ cells and presorted CD45- liver cells. Conclusion: We obtained liver specific Prom1+ genes from analysis.

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Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [scRNA-seq]

Project description:Purpose: The goal of the study is to understand gene expression profiles of Prom1+ cells at single cell level in mouse liver cancer. Method: DEN-WAD liver from Col1a1Cre;Rosa26mTmG was perfused with collagenase. GFP+UV- cells were FACSsorted. Single cell library was constructed with 10X single gene expression v3 with 10X chromium technology. Conclusion: We identified Prom1+Afp+, Prom1+Afp-, Prom1-Afp+ gene expression profiles. These gene expression profiles revealed the markers previously observed for liver tumor intiating cells and ductular cells. In addition, they revealed novel specific markers.

2020-12-17 | GSE152707 | GEO

Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer

Project description:Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer

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Drug-induced liver injury

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-22 | E-GEOD-54257 | biostudies-arrayexpress

Hippo Pathway Activity Influences Liver Cell Fate

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [Quant-seq]

Project description:Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [Quant-seq]

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Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [scRNA-seq]

Project description:Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [scRNA-seq]

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Drug-induced liver injury

Project description:This SuperSeries is composed of the SubSeries listed below.

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Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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