Methylation profiling

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Analysis of fetal livers from male mice after protein-restricted diet in mothers


ABSTRACT: Prenatal nutrition as influenced by nutritional status of the mother has been identified as a determinant of adult disease. Feeding low-protein diets during pregnancy in rodents is a well-established model to induce “programming” events in offspring. We hypothesized that protein restriction would influence fetal lipid metabolism by inducing epigenetic adaptations. Methodology/Principal Findings: Pregnant C57BL/6J OlaHsd mice were exposed to a protein restriction protocol (9% vs. 18% casein). Shortly before birth, dams and fetuses were sacrificed. To identify putative epigenetic changes, CpG island methylation microarrays were performed on DNA isolated from fetal livers.

ORGANISM(S): Mus musculus

PROVIDER: GSE15280 | GEO | 2009/11/03

SECONDARY ACCESSION(S): PRJNA116505

REPOSITORIES: GEO

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