Proteasome Inhibition Targets the KMT2A Transcriptional Complex

ABSTRACT: We quantitatively evaluated H2Bub and H3K79me2 epigenetic marks genome wide in a KMT2A rearranged B lineage acute lymphoblastic leukemia cell line after treatment with bortezomib over a 6 hour time course by ChIP-Rx. We identified rapid and concordant depletion of these epigenetic marks within two hours. To look at gene expression changes, RNA sequencing was performed on KMT2A rearranged B lineage acute lymphoblastic leukemia patient samples in the presence and absence of bortezomib exposure.

ORGANISM(S): Homo sapiens

PROVIDER: GSE152816 | GEO | 2022/01/13

REPOSITORIES: GEO