Measuring the dependence of the yeast heat shock response on intracellular pH and translation during stress

ABSTRACT: S. cerevisiae cells acidify when they experience stressful temperatures. In addition, newly-translated proteins are thought to misfold, triggering the heat shock response. To determine whether heat-shock associated acidification and translation state are important for the cellular response, we manipulated intracellular pH, blocked translation, heat shocked cells, and sequenced the transcriptome.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE152916 | GEO | 2020/06/30

REPOSITORIES: GEO