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RNA-sequence analysis of mouse AAA samples obtained from wild type mice and PSGL-1-/- mice induced by DOCA plus salt or not

ABSTRACT: We report the transcriptomic analysis of RNA-seq of abdominal aortas isolated from WT and PSGL-1-/- mice exposed to deoxycorticosterone acetate (DOCA) plus salt to uncover the mechanisms underlying the undefined role of PSGL-1 in abdominal aortic aneurysm (AAA)

ORGANISM(S): Mus musculus

PROVIDER: GSE153425 | GEO | 2020/12/31

REPOSITORIES: GEO

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RNA-sequence analysis of mouse AAA samples obtained from ApoE-/- and ApoE-/-Nur77-/- mice induced by Ang II

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Adventitial tertiary lymphoid organs in AAA are a potential source of miRNAs as biomarkers

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Angiotensin II induced aneurysms in male ApoE mice

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High-salt diet leads to differential gene expression in DOCA-treated mice

Project description:In the present study we made use of the (1-renin) DOCA-salt mouse model - which has been previously shown to develop cardiac and renal hypertrophy - to evaluate the direct effects of high-salt diet on cardiac function and gene expression profiling. The comparison between low-salt and high-salt DOCA-treated mice will reveal what genes are directly modulated by sodium in (normotensive) DOCA-treated mice. Previous publications: Wang Q, Hummler E, Nussberger J, Clement S, Gabbiani G, Brunner HR, Burnier M. Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of renin genes. J Am Soc Nephrol. 2002;13:1509 –1516. Wang Q, Domenighetti AA, Pedrazzini T, Burnier M. Potassium supplementation reduces cardiac and renal hypertrophy independent of blood pressure in DOCA/salt mice. Hypertension. 2005 Sep;46(3):547-54. Keywords: comparative dose-response treatment (2 groups)

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