Primary Human Airway Epithelial Cultures infected with SARS-CoV-2

ABSTRACT: We performed RNAseq analysis on primary human airway epithelial cultures either mock infected (PBS) or infected with SARS-CoV-2. Transcriptional profiling studies found that infected pHAE cells had a molecular signature dominated by pro-inflammatory cytokines and chemokine induction, including IL-6, TNFα, CXCL8, and identified NF-κB and ATF4 as key drivers of this pro-inflammatory cytokine response. Surprisingly, we observed a lack of a type I or III interferon (IFN) response to SARS-CoV-2 infection

ORGANISM(S): Homo sapiens

PROVIDER: GSE153970 | GEO | 2020/07/21

REPOSITORIES: GEO