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High fat diet inhibits EV-Mediated angiogenisis

ABSTRACT: Mesenchymal stem cell-derived extracellular vesicles (EVs) have been shown to promote angiogenesis in the ischemic myocardium. This study examines the difference in vascular density, myocardial perfusion, molecular signaling, and gene expression between normal diet (ND) and high fat diet (HFD) groups at baseline and following intra-myocardial injection of EVs We used GeneChip Gene Arrays for whole-transcriptome analysis between normal diet and high fat diet groups at baseline and following intra-myocardial injection of Evs.

ORGANISM(S): Sus scrofa

PROVIDER: GSE154028 | GEO | 2020/07/09

REPOSITORIES: GEO

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