Integrator-PP2A complex dephosphorylates the C-terminal repeat domain of RNA Polymerase II

ABSTRACT: The phosphorylation and dephosphorylation of transcription machinery are essential for the precise control of gene expression. A non-canonical protein phosphatase 2A (PP2A) holoenzyme (denoted INTAC), in which the 14-subunit Integrator recruits RNA polymerase II (Pol II) and the PP2A core enzyme dephosphorylates the C-terminal repeat domain (CTD) of Pol II at Serine-5 and Serine-2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154093 | GEO | 2020/12/02

REPOSITORIES: GEO