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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154100 | GEO | 2025/11/20

REPOSITORIES: GEO

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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [RNA-seq]

Project description:Here, we mapped the binding sites of PAXT/ZFC3H1, NEXT/ZCCHC8 and their shared MTR4 helicase subunit. Our data highlight a key interplay between cohesin-mediated long-range interactions in 3D and ncRNA regulation by MTR4 helicase and nuclear RNA exosome.

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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [ChIP-seq]

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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts

Project description:PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts

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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [ChIP-seq]

Project description:PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [ChIP-seq]

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PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts [RNA-seq]

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Activity-induced gene expression and long-range enhancer-promoter contacts in cohesin-deficient neurons

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