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Long-term longitudinal analysis of peripheral blood transcriptome in COVID-19 patients

ABSTRACT: We performed the longitudinal peripheral blood transcriptome profiling after diagnosis in five patients, and found that patients' blood transcriptomes undergo dramatic and consistent changes in early recovery stage (ERS). Meanwhile, the blood transcriptome did not fully return to the healthy state even after more than one month of recovery. We also realized that differential expressed genes (DEGs) are enriched in biological processes of antigen processing and related processes, and promoter regions of these genes enrich key transcription factors (TFs) involved in T cell differentiation and activation. We further provided potential mechanisms underlying these orchestrated processes, by revealing these specific TFs mediated gene co-expression network.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154272 | GEO | 2022/04/12

REPOSITORIES: GEO

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