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RNA-Seq to identify NMUR-1-regulated genes in C. elegans defense against pathogen infection

ABSTRACT: To gain molecular insights on how NMUR-1 regulates C. elegans defense against pathogen infection, we used RNA-Seq to profile gene expression in nmur-1(ok1387) animals relative to wild-type animals with or without E. faecalis or S. enterica infection. We found that NMUR-1 modulates C. elegans transcription activity by regulating the expression of transcription factors, which, in turn, controls the expression of distinct immune genes in response to different pathogens.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE154324 | GEO | 2022/02/28

REPOSITORIES: GEO

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