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Neonatal Blood Spots from the Emory University African American Microbiome in Pregnancy Cohort

ABSTRACT: Newborn screening blood spots were obtained for neonates born to women enrolled in the Emory University African American Microbiome in Pregnacy Cohort

ORGANISM(S): Homo sapiens

PROVIDER: GSE154446 | GEO | 2021/07/01

REPOSITORIES: GEO

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Emory University African American Microbiome in Pregnancy Cohort.

Project description:All subjects were enrolled from Grady Memorial and Emory Midtown Hospitals. Subjects provided blood samples at two timepoints during pregnancy.

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Emory University African American Microbiome in Pregnancy Cohort [expression]

Project description:All subjects were enrolled from Grady Memorial and Emory Midtown Hospitals. Subjects provided blood samples at two timepoints during pregnancy. Medical record abstraction was used to determine the presence of fetal intolerance of labor.

2018-03-19 | GSE107437 | GEO

Emory University African American Microbiome in Pregnancy Cohort [Methylation]

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Neonatal Blood Spots from the Emory University African American Microbiome in Pregnancy Cohort

Project description:Neonatal Blood Spots from the Emory University African American Microbiome in Pregnancy Cohort

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Emory University African American Microbiome in Pregnancy Cohort

Project description:Emory University African American Microbiome in Pregnancy Cohort

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Emory University African American Microbiome in Pregnancy Cohort.

Project description:Emory University African American Microbiome in Pregnancy Cohort.

| PRJNA504950 | ENA

Emory University African American Microbiome in Pregnancy Cohort [expression]

Project description:Emory University African American Microbiome in Pregnancy Cohort [expression]

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Emory University African American Microbiome in Pregnancy Cohort [Methylation]

Project description:Emory University African American Microbiome in Pregnancy Cohort [Methylation]

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Emory University African American Microbiome in Pregnancy Cohort

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-03-19 | GSE107460 | GEO

Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

Project description:The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared to European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical parameters. We also evaluated 18 non-tumor prostate tissues from 7 African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate less than 5%, to be differently expressed between African-American and European-American patients. Using a disease association analysis, we identified a common relationship of these transcripts with autoimmunity and inflammation. These findings were corroborated on the pathway level with numerous differently expressed genes clustering in immune response, stress response, cytokine signaling, and chemotaxis pathways. Furthermore, a two-gene tumor signature was identified that accurately differentiated between African-American and European-American patients. This finding was confirmed in a blinded analysis of a second sample set. In conclusion, the gene expression profiles of prostate tumors indicate prominent differences in tumor immunobiology between African-American and European-American men. The profiles portray the existence of a distinct tumor microenvironment in these two patient groups. Keywords: Microdissected tissue analysis

2008-01-01 | GSE6956 | GEO

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