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RNA-seq profiling of A549 cells with sgRNA knockouts that confer prexasertib resistance

ABSTRACT: A549 cells with FOXM1 or LIN54 sgRNA knockout, which confers resistance to the CHK1 inhibitor prexasertib, were generated. These cells and control (empty vector) cells were synchronized in S phase, released for 1 hour and treated with 100 nM prexasertib or DMSO (vehicle) for 2 hours. RNA-seq profiling was performed to identify drug-induced perturbations in gene expression in these cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE154545 | GEO | 2021/02/24

REPOSITORIES: GEO

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