Single Cell Profiling of DNMT3A-Mutant Progenitors Novel Pre-Leukemia Marker and Potential Therapeutic Target

ABSTRACT: To identify early events involved in pre-leukemic transformation, we have performed single-cell RNA-sequencing (scRNA-seq) in WT and Dnmt3a KO mice. Flow cytometry sorted wild-type and pre-leukemic Dnmt3a KO HSPC cells were captured using 10X genomics chromium platform.

ORGANISM(S): Mus musculus

PROVIDER: GSE154624 | GEO | 2021/12/01

REPOSITORIES: GEO