Distinct bacterial pathways influence the efficacy of antibiotics against Mycobacterium tuberculosis

ABSTRACT: Understanding how M. tuberculosis survives during antibiotic treatment is necessary to rationally devise more effective tuberculosis chemotherapy regimens. Using genome-wide mutant fitness profiling and the mouse model of TB, we identified genes that alter antibiotic efficacy specifically in the infection environment.

ORGANISM(S): Mycobacterium tuberculosis H37Rv

PROVIDER: GSE154627 | GEO | 2020/07/18

REPOSITORIES: GEO