Loss of tight junction integrity induces loss of epithelial phenotype: case of Claudin11 knock out in testis.

ABSTRACT: Epithelium barrier integrity is assumed at least in part by the presence of junctions between cells. Tight-junction formation may be necessary for Sertoli cells to cease dividing and to support germ cell development. Microarray analysis of P20 Cldn11 +/- and Cldn11-/- testes confirmed the impact od Cldn11 deficiency on cell cytoskeleton and junction-related genes. Keywords: transcriptomic analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE15492 | GEO | 2010/04/11

SECONDARY ACCESSION(S): PRJNA115939

REPOSITORIES: GEO