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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

ABSTRACT: Single cell sequencing of Ins2-Cre;ptdTomato+ FACS sorted cells from micro-dissected hypothalamic arcuate nucleus and median eminence of wildtype and Irx3/5 double heterozygous mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE154969 | GEO | 2021/02/18

REPOSITORIES: GEO

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (DROP-seq)

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

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Next Generation Sequencing of BMDM overexpressing GFP, IRX3-WT, IRX3-S361A and IRX3-S389A

Project description:IRX3 is a transcriptional factor, which play important functions in developmental processes. But the role of IRX3 in immune cells are less studied. So we sequenced mRNA from BMDMs overexpressing GFP, IRX3, as well as two phosphorylation site mutants-S361A and S389A respectively, to address the roles of IRX3 in macrophages.

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Tao et al. BioID of Irx3 and Irx5

Project description:This submission contains the mass spectrometry files for the manuscript by Tao et al. that describes the characterization of the two transcription factors Irx3 and Irx5 and their role in regulating sister chromatid segregation. This submission contains 8 DDA files for the following baits: BirA*-FLAG-Irx3, BirA*-FLAG-Irx5, BirA*-FLAG-GFP (control) and BirA* (control).

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Project description:Irx3 and Irx5 are important for oocyte and follicle survival within the developing ovary, but their regulation had not been elucidated. Methods: XX and XY supporting cells of the gonad were FACS-purified at E13.5, and submitted to ChIP-seq for H3K27me3 and H3 as a means to normalize across cell populations. Results: We identified TCF/LEF-binding sequences within two distal enhancers of the IrxB locus that promote β-catenin responsive ovary expression. Meanwhile, Irx3 and Irx5 transcription is suppressed within the developing testis by the presence of H3K27me3 on these same sites.

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